hNQO1-Activatable Fluorescent Dye for Cancer Invitro & Invivo Imaging - Bok av Hanumantha Rao Madala, Surendra Reddy Pungauru, m.fl. - Häftad
Human NAD(P)H quinone oxidoreductase-1 (hNQO1) is an important cancer-related biomarker, which shows significant overexpression in malignant cells. Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management. In the present study, we report a new dicyanoisophorone (DCP) based fluorescent probe (NQ-DCP) capable of monitoring hNQO1 activity in vitro and in vivo in both ratiometric..
