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Women Architects in the Modern Movement

Bayesian Applications in Pharmaceutical Development

Bayesian Applications in Pharmaceutical Development

The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2. 6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development from discovery to clinical trial to manufacturing with practical examples. This book will have a wide appeal to statisticians scientists and physicians working in drug development who are motivated to accelerate and streamline the drug development process as well as students who aspire to work in this field. The advantages of this book are: Provides motivating worked practical case examples with easy to grasp models technical details and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles technical reports and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University Dallas Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process. | Bayesian Applications in Pharmaceutical Development

GBP 44.99
1

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Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

As pharmaceutical companies strive to develop safer medicines at a lower cost they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work Process Chemistry in the Pharmaceutical Industry Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic physical and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis clinical trials and commercializing drug candidates. The second installment in this progressive series this volumereviews the latest breakthroughs to advance process chemistry including asymmetric synthesis crystallization morphology enzymatic intervention green chemistry macromolecules (monoclonal antibodies biological molecules polymers) enantioselectivity organometallic chemistry process analytical tools chemical engineering controls regulatory compliance and outsourcing/globalization. It explores new approaches to synthetic processes examines the latest safety methods and experiment design and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy ease of synthesis instrumentation automization quality control cost considerations green practices and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer this book brings together contributions byreputed scientists technologists engineers and professors from leading academic institutions such as the Imperial College UK the University of Tokyo ETH Switzerland the International University at Bermen Germany and the University of Connecticut USA and from principal pharmaceutical companies that include Merck Bristol Myers Squibb Pfizer Novartis Eli Lilly Astrazeneca and DSM. | Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

GBP 44.99
1

Games Gambling and Probability An Introduction to Mathematics

Games Gambling and Probability An Introduction to Mathematics

Many experiments have shown the human brain generally has very serious problems dealing with probability and chance. A greater understanding of probability can help develop the intuition necessary to approach risk with the ability to make more informed (and better) decisions. The first four chapters offer the standard content for an introductory probability course albeit presented in a much different way and order. The chapters afterward include some discussion of different games different ideas that relate to the law of large numbers and many more mathematical topics not typically seen in such a book. The use of games is meant to make the book (and course) feel like fun! Since many of the early games discussed are casino games the study of those games along with an understanding of the material in later chapters should remind you that gambling is a bad idea; you should think of placing bets in a casino as paying for entertainment. Winning can obviously be a fun reward but should not ever be expected. Changes for the Second Edition: New chapter on Game Theory New chapter on Sports Mathematics The chapter on Blackjack which was Chapter 4 in the first edition appears later in the book. Reorganization has been done to improve the flow of topics and learning. New sections on Arkham Horror Uno and Scrabble have been added. Even more exercises were added! The goal for this textbook is to complement the inquiry-based learning movement. In my mind concepts and ideas will stick with the reader more when they are motivated in an interesting way. Here we use questions about various games (not just casino games) to motivate the mathematics and I would say that the writing emphasizes a just-in-time mathematics approach. Topics are presented mathematically as questions about the games themselves are posed. Table of Contents Preface1. Mathematics and Probability 2. Roulette and Craps: Expected Value 3. Counting: Poker Hands 4. More Dice: Counting and Combinations and Statistics 5. Game Theory: Poker Bluffing and Other Games 6. Probability/Stochastic Matrices: Board Game Movement 7. Sports Mathematics: Probability Meets Athletics 8. Blackjack: Previous Methods Revisited 9. A Mix of Other Games 10. Betting Systems: Can You Beat the System? 11. Potpourri: Assorted Adventures in Probability Appendices Tables Answers and Selected Solutions Bibliography Biography Dr. David G. Taylor is a professor of mathematics and an associate dean for academic affairs at Roanoke College in southwest Virginia. He attended Lebanon Valley College for his B. S. in computer science and mathematics and went to the University of Virginia for his Ph. D. While his graduate school focus was on studying infinite dimensional Lie algebras he started studying the mathematics of various games in order to have a more undergraduate-friendly research agenda. Work done with two Roanoke College students Heather Cook and Jonathan Marino appears in this book! Currently he owns over 100 different board games and enjoys using probability in his decision-making while playing most of those games. In his spare time he enjoys reading cooking coding playing his board games and spending time with his six-year-old dog Lilly. | Games Gambling and Probability An Introduction to Mathematics

GBP 82.99
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